Synthesis and Evaluation of Anisomelic acid-like Compounds for the

Bsa protein

Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Fang Cheng, Maria Sippola-Thiele, Patrik Eklund and John E Eriksson. Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner. Acridine Orange & Ethidium Bromide (AO & EB) and Hoechst 33258 staining Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells.The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- … Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles mal - abarica .

A1 Originalartikel i en vetenskaplig tidskrift Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas (2019) Senthilkumar R, Brusentsev Y, Paul P, Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect2015Ingår i: Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect. av bröd Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular The bicinchoninic acid assay (BCA assay), also known as the Smith assay, Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular Dynamic mode and the dynamic behavior of AA with HSA and BSA. bsa protein Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular Dynamic mode and the dynamic behavior of AA with HSA and BSA. kDa large protein Plasma Protein Binding of Anisomelic Acid: Spectroscopy and Molecular The bicinchoninic acid assay (BCA assay), also known as the Smith assay, after its ANISOMELIC ACID (6E,10Z,14Z)-6,14-dimethyl-3-methylidene-2-oxo-3a,4,5,8,9,12,13,15a-octahydrocyclotetradeca[b]furan-10-carboxylic acid. 59632-76-7 HPV-mediated cancers. Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins. The present study describes the structure-activity relationship and the evaluation of synthetic AA like Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles malabarica. Recently, we have studied the mode of action of AA-mediated apoptosis, indicating Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity.

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Targeted delivery of a novel anticancer compound anisomelic

13:2002-2006. Activities (22) Anthelmintic AntiHIV EC50=2.0 ug/ml Kashiwada, Y Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity. However, to date, the plasma protein binding properties of AA are unknown.

Targeted delivery of a novel anticancer compound anisomelic

Mohammad Akbarsha. Preethy Paul. Ali Alshatwi. Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Scientific Reports , Mar 2020 Rajendran Senthilkumar , Yury Brusentsev , Preethy Paul , Parthiban Marimuthu , Fang Cheng , Patrik C. Eklund , John Elias Eriksson Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. CAM, cIAP2, HPV: 5 : 2013: Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells. In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP).

Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. CAM, cIAP2, HPV: 5 : 2013: Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. A pharmaceutical composition for anti-viral cancer treatment in mammals, comprising a therapeutically effective amount of Anisomelic acid or salts thereof. The pharmaceutical composition may comprise Anisomelic acid or salt thereof in an oil-in-water emulsion, for example in an isotropic mixture of at least one oil and at least one surfactant or, alternatively, in a hydrophilic solvent and a Anisomelic acid, is one of the major compounds in Anisomeles malabarica (L.) R. Br., is a cembrane type diterpenoid, which can be synthesized chemically.
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Sci Rep. 2019 Dec 30;9(1):20295.

Examples of strong acids are listed. A strong acid is one that is completely dissociated or ionized in an aqueous solution.
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Targeted delivery of a novel anticancer compound anisomelic

Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate. Top Interacting Genes. MeSH® ID, D004224.

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FI126047B - Pharmaceutical compositions of anisomelic acid and

AA is revealed to hold a novel action modality based on specific targeting of the HPV oncoproteins, which restores p53-mediated growth arrest and induces apoptosis by terminating E6-mediated cIAP2 stabilization.